Pesquisa | BVS IEC

1.

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

Yeung, Man Lung; Teng, Jade Lee Lee; Jia, Lilong; Zhang, Chaoyu; Huang, Chengxi; Cai, Jian-Piao; Zhou, Runhong; Chan, Kwok-Hung; Zhao, Hanjun; Zhu, Lin; Siu, Kam-Leung; Fung, Sin-Yee; Yung, Susan; Chan, Tak Mao; To, Kelvin Kai-Wang; Chan, Jasper Fuk-Woo; Cai, Zongwei; Lau, Susanna Kar Pui; Chen, Zhiwei; Jin, Dong-Yan; Woo, Patrick Chiu Yat; Yuen, Kwok-Yung.

Cell ; 184(8): 2212-2228.e12, 2021 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-33713620

2.

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

Yeung, Man Lung; Teng, Jade Lee Lee; Jia, Lilong; Zhang, Chaoyu; Huang, Chengxi; Cai, Jian-Piao; Zhou, Runhong; Chan, Kwok-Hung; Zhao, Hanjun; Zhu, Lin; Siu, Kam-Leung; Fung, Sin-Yee; Yung, Susan; Chan, Tak Mao; To, Kelvin Kai-Wang; Chan, Jasper Fuk-Woo; Cai, Zongwei; Lau, Susanna Kar Pui; Chen, Zhiwei; Jin, Dong-Yan; Woo, Patrick Chiu Yat; Yuen, Kwok-Yung.

Cell ; 186(24): 5428-5432, 2023 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-37995658

3.

Decreased risk of non-influenza respiratory infection after influenza B virus infection in children.

Tsang, Tim K; Du, Richael Q R; Fang, Vicky J; Lau, Eric H Y; Chan, Kwok Hung; Chu, Daniel K W; Ip, Dennis K M; Peiris, J S Malik; Leung, Gabriel M; Cauchemez, Simon; Cowling, Benjamin J.

Epidemiol Infect ; 152: e60, 2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38584132

4.

The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac.

Ng, Ho-Yu; Liao, Yunshi; Zhang, Ruiqi; Chan, Kwok-Hung; To, Wai-Pan; Hui, Chun-Him; Seto, Wai-Kay; Leung, Wai K; Hung, Ivan F N; Lam, Tommy T Y; Cheung, Ka-Shing.

Int J Mol Sci ; 25(5)2024 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-38473829

5.

Early Treatment of High-Risk Hospitalized Coronavirus Disease 2019 (COVID-19) Patients With a Combination of Interferon Beta-1b and Remdesivir: A Phase 2 Open-label Randomized Controlled Trial.

Tam, Anthony Raymond; Zhang, Ricky Ruiqi; Lung, Kwok-Cheung; Liu, Raymond; Leung, Ka-Yi; Liu, Danlei; Fan, Yujing; Lu, Lu; Lam, Athene Hoi-Ying; Chung, Tom Wai-Hin; Yip, Cyril Chik-Yan; Lo, Jenny; Wu, Alan Ka-Lun; Lee, Rodney; Sin, Simon; Ng, Pauline Yeung; Chan, Wai-Ming; Shum, Hoi-Ping; Yan, Wing-Wa; Chan, Jasper Fuk-Woo; Cheng, Vincent Chi-Chung; Lau, Chak-Sing; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Yuen, Kwok-Yung; Hung, Ivan Fan-Ngai.

Clin Infect Dis ; 76(3): e216-e226, 2023 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-35762834

6.

Autoantibodies against angiotensin-converting enzyme 2 (ACE2) after COVID-19 infection or vaccination.

Tsoi, James Yiu Hung; Cai, Jianpiao; Situ, Jianwen; Lam, Winston Jim; Shun, Estie Hon Kiu; Leung, Joy Ka Yi; Chen, Lin Lei; Chan, Brian Pui Chun; Yeung, Man Lung; Li, Xin; Chan, Kwok Hung; Wong, Joshua Sung Chih; Kwan, Mike Yat Wah; To, Kelvin Kai Wang; Yuen, Kwok Yung; Sridhar, Siddharth.

J Med Virol ; 95(12): e29313, 2023 12.

Artigo em Inglês | MEDLINE | ID: mdl-38100626

7.

Difference in clinical features of SARS-CoV-2 in pediatric patients before and after emergence of P.1.

Leung, Char; Khong, Ka-Wah; Chan, Kwok-Hung; Lacerda, Marcus Vinicius Guimarães; Frank, Carlos Henrique Michiles.

Pediatr Res ; 93(1): 176-182, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-35418598

8.

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant-Associated Receptor Binding Domain (RBD) Mutations on the Susceptibility to Serum Antibodies Elicited by Coronavirus Disease 2019 (COVID-19) Infection or Vaccination.

Chen, Lin-Lei; Lu, Lu; Choi, Charlotte Yee-Ki; Cai, Jian-Piao; Tsoi, Hoi-Wah; Chu, Allen Wing-Ho; Ip, Jonathan Daniel; Chan, Wan-Mui; Zhang, Ricky Ruiqi; Zhang, Xiaojuan; Tam, Anthony Raymond; Lau, Daphne Pui-Ling; To, Wing-Kin; Que, Tak-Lun; Yip, Cyril Chik-Yan; Chan, Kwok-Hung; Cheng, Vincent Chi-Chung; Yuen, Kwok-Yung; Hung, Ivan Fan-Ngai; To, Kelvin Kai-Wang.

Clin Infect Dis ; 74(9): 1623-1630, 2022 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-34309648

9.

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients.

Lu, Lu; Mok, Bobo Wing Yee; Chen, Lin Lei; Chan, Jacky Man Chun; Tsang, Owen Tak Yin; Lam, Bosco Hoi Shiu; Chuang, Vivien Wai Man; Chu, Allen Wing Ho; Chan, Wan Mui; Ip, Jonathan Daniel; Chan, Brian Pui Chun; Zhang, Ruiqi; Yip, Cyril Chik Yan; Cheng, Vincent Chi Chung; Chan, Kwok Hung; Jin, Dong Yan; Hung, Ivan Fan Ngai; Yuen, Kwok Yung; Chen, Honglin; To, Kelvin Kai Wang.

Clin Infect Dis ; 75(1): e822-e826, 2022 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-34915551

10.

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.

Chan, Jasper Fuk Woo; Poon, Vincent Kwok Man; Chan, Chris Chung Sing; Chik, Kenn Ka Heng; Tsang, Jessica Oi Ling; Zou, Zijiao; Chan, Chris Chun Yiu; Lee, Andrew Chak Yiu; Li, Can; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Yuen, Terrence Tsz Tai; Hu, Bingjie; Huang, Xiner; Chai, Yue; Shuai, Huiping; Luo, Cuiting; Cai, Jian Piao; Chan, Kwok Hung; Sridhar, Siddharth; Yin, Feifei; Kok, Kin Hang; Chu, Hin; Zhang, Anna Jinxia; Yuan, Shuofeng; Yuen, Kwok Yung.

Clin Infect Dis ; 75(1): e1101-e1111, 2022 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-34536277

11.

Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong.

Chan, Jasper Fuk Woo; Siu, Gilman Kit Hang; Yuan, Shuofeng; Ip, Jonathan Daniel; Cai, Jian Piao; Chu, Allen Wing Ho; Chan, Wan Mui; Abdullah, Syed Muhammad Umer; Luo, Cuiting; Chan, Brian Pui Chun; Yuen, Terrence Tsz Tai; Chen, Lin Lei; Chik, Kenn Ka Heng; Liang, Ronghui; Cao, Hehe; Poon, Vincent Kwok Man; Chan, Chris Chung Sing; Leung, Kit Hang; Tam, Anthony Raymond; Tsang, Owen Tak Yin; Chan, Jacky Man Chun; To, Wing Kin; Lam, Bosco Hoi Shiu; Lee, Lam Kwong; Lo, Hazel Wing Hei; Wong, Ivan Tak Fai; Leung, Jake Siu Lun; Wong, Evelyn Yin Kwan; Chu, Hin; Yip, Cyril Chik Yan; Cheng, Vincent Chi Chung; Chan, Kwok Hung; Tse, Herman; Lung, David Christopher; Ng, Kenneth Ho Leung; Au, Albert Ka Wing; Hung, Ivan Fan Ngai; Yuen, Kwok Yung; To, Kelvin Kai Wang.

Clin Infect Dis ; 75(1): e76-e81, 2022 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-35234870

12.

Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle.

Yang, Fang; Pang, Bo; Lai, Kin Kui; Cheung, Nam Nam; Dai, Jun; Zhang, Weizhe; Zhang, Jinxia; Chan, Kwok-Hung; Chen, Honglin; Sze, Kong-Hung; Zhang, Hongmin; Hao, Quan; Yang, Dan; Yuen, Kwok-Yung; Kao, Richard Y.

J Virol ; 95(9)2021 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-33627391

13.

Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection.

To, Kelvin Kai-Wang; Hung, Ivan Fan-Ngai; Chan, Kwok-Hung; Yuan, Shuofeng; To, Wing-Kin; Tsang, Dominic Ngai-Chong; Cheng, Vincent Chi-Chung; Chen, Zhiwei; Kok, Kin-Hang; Yuen, Kwok-Yung.

Clin Infect Dis ; 72(10): e659-e662, 2021 05 18.

Artigo em Inglês | MEDLINE | ID: mdl-32966566

14.

A Double-blind, Randomized Phase 2 Controlled Trial of Intradermal Hepatitis B Vaccination With a Topical Toll-like Receptor 7 Agonist Imiquimod, in Patients on Dialysis.

Hung, Ivan Fan-Ngai; Yap, Desmond Yat-Hin; Yip, Terence Pok-Siu; Zhang, Ricky Ruiqi; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Tang, Sydney Chi-Wai; Lui, Sing-Leung; Levin, Yotam; Kochba, Efrat; Lau, Johnson Yiu-Nam; Yuen, Man-Fung; Chan, Tak-Mao; Yuen, Kwok-Yung.

Clin Infect Dis ; 73(2): e304-e311, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-32556176

15.

Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing.

To, Kelvin Kai-Wang; Hung, Ivan Fan-Ngai; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Tam, Anthony Raymond; Fong, Carol Ho-Yan; Yuan, Shuofeng; Tsoi, Hoi-Wah; Ng, Anthony Chin-Ki; Lee, Larry Lap-Yip; Wan, Polk; Tso, Eugene Yuk-Keung; To, Wing-Kin; Tsang, Dominic Ngai-Chong; Chan, Kwok-Hung; Huang, Jian-Dong; Kok, Kin-Hang; Cheng, Vincent Chi-Chung; Yuen, Kwok-Yung.

Clin Infect Dis ; 73(9): e2946-e2951, 2021 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-32840608

16.

Unique Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 Causing a Large Coronavirus Disease 2019 Outbreak in Hong Kong.

To, Kelvin Kai-Wang; Chan, Wan-Mui; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Tam, Anthony Raymond; Liu, Raymond; Wu, Alan Ka-Lun; Lung, Kwok-Cheung; Tsang, Owen Tak-Yin; Lau, Daphne Pui-Ling; To, Wing-Kin; Kwan, Mike Yat-Wah; Yau, Yat-Sun; Ng, Anthony Chin-Ki; Yip, Cyril Chik-Yan; Chan, Kwok-Hung; Tse, Herman; Hung, Ivan Fan-Ngai; Yuen, Kwok-Yung.

Clin Infect Dis ; 73(1): 137-142, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-32756996

17.

Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model.

Li, Can; Chen, Yan-Xia; Liu, Fei-Fei; Lee, Andrew Chak-Yiu; Zhao, Yan; Ye, Zhan-Hong; Cai, Jian-Piao; Chu, Hin; Zhang, Rui-Qi; Chan, Kwok-Hung; Chiu, Kelvin Hei-Yeung; Lung, David Christopher; Sridhar, Siddharth; Hung, Ivan Fan-Ngai; To, Kelvin Kai-Wang; Zhang, Anna Jin-Xia; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Clin Infect Dis ; 73(3): e719-e734, 2021 08 02.

Artigo em Inglês | MEDLINE | ID: mdl-33515458

18.

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chu, Hin; Yang, Jin; Xing, Fanfan; Liu, Jieling; Yip, Cyril Chik-Yan; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Lo, Simon Kam-Fai; Chan, Kwok-Hung; Poon, Vincent Kwok-Man; Chan, Wan-Mui; Ip, Jonathan Daniel; Cai, Jian-Piao; Cheng, Vincent Chi-Chung; Chen, Honglin; Hui, Christopher Kim-Ming; Yuen, Kwok-Yung.

Lancet ; 395(10223): 514-523, 2020 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-31986261

19.

Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.

Hung, Ivan Fan-Ngai; Lung, Kwok-Cheung; Tso, Eugene Yuk-Keung; Liu, Raymond; Chung, Tom Wai-Hin; Chu, Man-Yee; Ng, Yuk-Yung; Lo, Jenny; Chan, Jacky; Tam, Anthony Raymond; Shum, Hoi-Ping; Chan, Veronica; Wu, Alan Ka-Lun; Sin, Kit-Man; Leung, Wai-Shing; Law, Wai-Lam; Lung, David Christopher; Sin, Simon; Yeung, Pauline; Yip, Cyril Chik-Yan; Zhang, Ricky Ruiqi; Fung, Agnes Yim-Fong; Yan, Erica Yuen-Wing; Leung, Kit-Hang; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Ng, Anthony Chin-Ki; Lee, Rodney; Fung, Kitty; Yeung, Alwin; Wu, Tak-Chiu; Chan, Johnny Wai-Man; Yan, Wing-Wah; Chan, Wai-Ming; Chan, Jasper Fuk-Woo; Lie, Albert Kwok-Wai; Tsang, Owen Tak-Yin; Cheng, Vincent Chi-Chung; Que, Tak-Lun; Lau, Chak-Sing; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Lancet ; 395(10238): 1695-1704, 2020 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-32401715

20.

Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.

Li, Xin; Chan, Jasper Fuk-Woo; Li, Kenneth Kai-Wang; Tso, Eugene Yuk-Keung; Yip, Cyril Chik-Yan; Sridhar, Siddharth; Chung, Tom Wai-Hin; Chiu, Kelvin Hei-Yeung; Hung, Derek Ling-Lung; Wu, Alan Ka-Lun; Chau, Sandy Ka-Yee; Liu, Raymond; Lung, Kwok-Cheung; Tam, Anthony Raymond; Cheng, Vincent Chi-Chung; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Hung, Ivan Fan-Ngai; Yuen, Kwok-Yung.

Infection ; 49(2): 257-265, 2021 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-32944840

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Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

Decreased risk of non-influenza respiratory infection after influenza B virus infection in children.

The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac.

Early Treatment of High-Risk Hospitalized Coronavirus Disease 2019 (COVID-19) Patients With a Combination of Interferon Beta-1b and Remdesivir: A Phase 2 Open-label Randomized Controlled Trial.

Autoantibodies against angiotensin-converting enzyme 2 (ACE2) after COVID-19 infection or vaccination.

Difference in clinical features of SARS-CoV-2 in pediatric patients before and after emergence of P.1.

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant-Associated Receptor Binding Domain (RBD) Mutations on the Susceptibility to Serum Antibodies Elicited by Coronavirus Disease 2019 (COVID-19) Infection or Vaccination.

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients.

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.

Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong.

Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle.

Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection.

A Double-blind, Randomized Phase 2 Controlled Trial of Intradermal Hepatitis B Vaccination With a Topical Toll-like Receptor 7 Agonist Imiquimod, in Patients on Dialysis.

Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing.

Unique Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 Causing a Large Coronavirus Disease 2019 Outbreak in Hong Kong.

Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model.

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.

Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.